Denture Cream Linked to Zinc Poisoning, Copper Deficiency, Neuropathy and Permanent Nerve Damage

Last Updated April 26, 2022

[Update: Levin Simes is not currently investigating or accepting Denture Cream cases. This article will remain online for informational purposes only.]

Hundreds of Poligrip and Fixodent Users have reported numbness, tingling, and pain after developing unexplained Neuropathy. Recent Stuides show that Denture cream may cause zinc poisoning and copper deficiency and may lead to PERMANENT Nerve Damage.


Super Poligrip and Fixodent are denture cream products used to adhere dentures to the mouth so that consumers do not have to worry about slippage or denture movement. Super Poligrip, produced by GlaxoSmithKline healthcare company, and Fixodent, produced by Proctor and Gamble, are two of the most popular denture cream products. In recent studies, denture creams such as Fixodent and Super Poligrip have been linked to zinc poisoning, copper depletion, and permanent nerve damage (neuropathy).

Multiple media outlets began reporting on issues surrounding Denture Cream and the responses of the two leading manufacturers in early 2010. In February of 2010, GlaxoSmithKline announced that it would remove zinc from its denture adhesive products, due to numerous complaints. In addition, Proctor and Gamble put a small and hardly noticeable warning tab on its website. Hundreds of lawsuits have subsequently been filed against the makers of these denture creams

Denture Cream Usage

When used as recommended, a single tube of denture cream is expected to last for three to ten weeks. However, because the use of dentures is often thought of as embarrassing, many people overuse denture creams to ensure that dentures don’t slip. Medical problems often arise when individuals use two or more bottles of denture cream per week.

Denture creams contain zinc. Generally, the recommended daily allowance for zinc is 8mg for women and 11mg for men. The National Academy of Sciences estimated that the largest daily tolerable allowance of zinc is 40 mg. When denture cream is overused, the estimated exposure levels are 330mg, more than 8 times the maximum tolerable level and more than 40 times the recommended level. In response to high zinc levels, the body begins to deplete is level of copper, a metal necessary for red blood cell creation and various other key bodily functions.

Denture cream has also been shown to be linked to nervous disorders such as Neuropathy (damage to the nerves) and myelopathy (damage to spinal cord). Denture Cream has also been linked to poor liver and kidney function, resulting from zinc and copper imbalances

High zinc intake caused by denture creams such as Super Poligrip and Fixodent often lead to zinc poisoning, known as hyperzincuria. As a result of high zinc levels, the body lowers copper levels leading to copper depletion, known as hypocupremia. As a result, nervous disorders such as neuropathy and myelopathy have been linked to excessive use of Denture cream.

The diagnosis is based on blood level testing for high levels of zinc and low levels of copper. Normal blood levels of copper range from 0.75 to 1.45 micrograms per milliliter (mL), but levels for denture cream users ranged from less than 0.1 to 0.23 micrograms per mL.

In recent studies, patients showed only mild neurologic improvement after they quit using den-ture cream and began taking copper supplements, hence injuries are permanent


High Zinc (Hyperzincemia) and Low Copper (Hypocupremia):

  • Abdominal pain
  • Nausea
  • Vomiting
  • Anemia
  • Lethargy


  • Numbness
  • Tremor
  • Tingling
  • Cramps
  • Muscle Twitch

Other Symptoms:

  • Loss of Sensation
  • Loss of balance
  • Difficulty breathing
  • Kidney failure
  • Liver failure
  • Unexplained Paralysis
  • Bone Marrow Depletion

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[Update: Levin Simes is not currently investigating or accepting Denture Cream cases. This article will remain online for informational purposes only.]

Levin Simes Abrams